I used Lutris for anything Windows related that needs installers, etc. You can run that on pretty much anything.

As far as distros go it depends on how hands off you want it to be. If you want a set it and forget it distro I’d go with Fedora or Ubuntu.

If you want something more bleeding edge and customisable I’d go with EndeavourOS, which is basically Arch on rails.

I’ve been using Syncthing-Fork for a while now. It seems to work fine for me, however you do need to launch it occasionally as sometimes it can get killed when backgrounded depending on your flavour of Android.